Probiotics play a role in balancing the microbiota, making the gut epithelial lining strong and tight, and preventing unwanted substances from entering the bloodstream. Weizmannia coagulans Unique IS-2 or Bacillus coagulans Unique IS-2 as it was previously known is one such probiotic that can fit seamlessly into fermented foods, ingredients in food, or as food supplements and drugs. Being a high-temperature tolerant strain is what sets it apart from other probiotics in the market.

Bacillus coagulans Unique IS-2, the proprietary strain of Unique Biotech Ltd., is a natural, efficacious, versatile, resilient and safe probiotic. It is a gram-positive, facultatively anaerobic, non-pathogenic, spore-forming, lactic-acid-producing bacteria.

Bacillus coagulans Unique IS-2 being naturally encased in a hardened shell makes it the choicest probiotic for pharma, nutra and food applications. It can blend in dietary supplements, functional foods and beverages, without compromising on their sensory properties (taste, smell, appearance).

Benefits of Natural encapsulation


Benefits of Unique IS-2

Backed with 22+ clinical studies, Unique IS-2 is a thoroughly researched probiotic strain with health benefits that span across

Digestive Health and Gut Health

  • Promotes favorable gut flora
  • Improves digestion



Immune Health

  • Increases the production of anti-inflammatory cytokines
  • Effective in activating cell mediated immunity



 Gastrointestinal health

  • Gentle relief from constipation
  • Helps manage symptoms of IBS in children and adults
  • Reduces symptoms of IBD


Women’s health

  • Support and maintain healthy vaginal flora
  • Effective in the treatment of Bacterial Vaginosis


  Sports Nutrition

  • Enhanced protein absorption in athletes



Oral Health

  • Helps reduce dental carries in children
  • Improves symptoms of gingivitis

Our white paper gives an overview of the in vitro, in vivo and clinical studies conducted on Bacillus coagulans Unique IS-2. Additionally, it explores the mechanism of action and several health benefits of the strain.

Mechanism of Action

Ingested Bacillus coagulans spores 
are activated in the stomach due to
low gastric pH, water and mechanical
churning action
Bacillus coagulans spores 
germinate and multiply rapidly
Produces amylase, 
protease and lipase 
that aid in digestion
Produces volatile 
SCFAs and
which reduce the
pathogenic load
Produces L - 
(+) lactic acid
which inhibits
the growth of
As it is a transient probiotic, 
discontinuation of administration leads
to the excretion of the bacteria via
feces for approximately 7 days

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